A Possible Mechanism Underlying the Effectiveness of \ in the Treatment of Drug Addiction
Chae Ha Yang, Bong Hyo Lee, Sung Hoon Sohn
The reception waiting area at Acupuncture Zen in Delray Beach
With Acupuncture Treatment of Drug Addiction, as with cocaine, amphetamines, and morphine, nicotine addiction is believed to result from increased release of dopamine in the region of nucleus accumbens.[104,105] One study reported the effect of acupuncture on behavioral locomotor activity and c-fos expression in the nucleus accumbens and striatum utilizing the immunocytochemical detection of the Fos protein in nicotine-sensitized rats. Similar to morphine or ethanol-sensitized rats, acupuncture significantly attenuated the expected increase in nicotine-induced locomotor activity and FLI in the nucleus accumbens and striatum to subsequent nicotine challenge.[106] These findings suggest that acupuncture produces a therapeutic effect on nicotine addiction, possibly by modulating postsynaptic neuronal activity in the nucleus accumbens and the striatum.
Clinical trials are currently underway to determine the effectiveness of acupuncture in treating drug addiction.[15,107] Yet, there are still many unanswered questions about the basic mechanisms of acupuncture. Additional research using animal models is crucial in understanding the fundamental mechanisms of acupuncture. Chronic exposure to drugs of abuse produces a withdrawal state as reflected in increases in brain reward thresholds, and this change in reward threshold appears to be opposite to the actions of the drug administered acutely.
-Resources- Chae Ha Yang, Bong Hyo Lee, Sung Hoon Sohn
A Possible Mechanism Underlying the Effectiveness of Acupuncture in the Treatment of Drug Addiction
A randomized controlled trial of auricular acupuncture for cocaine dependence.
Avants SK, Margolin A, Holford TR, Kosten TR.
Source
Substance Abuse Center, Yale University School of Medicine, New Haven, CT 06519, USA.
RESULTS: Longitudinal analysis of the urine data for the intent-to-treat sample showed that patients assigned to acupuncture were significantly more likely to provide cocaine-negative urine samples relative to both the relaxation control (odds ratio, 3.41; 95% confidence interval, 1.33-8.72; P =. 01) and the needle-insertion control (odds ratio, 2.40; 95% confidence interval, 1.00-5.75; P =.05).
CONCLUSIONS:
Findings from the current study suggest that acupuncture shows promise for the treatment of cocaine dependence. Further investigation of this treatment modality appears to be warranted.
A randomized controlled trial of auricular acupuncture for cocaine dependence.
Acupuncture Treatment of Drug Addiction